| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-885 | |
| Phytochemical name or plant extracts | Daphne gnidium L. extract | |
| PMID | 19746845 | |
| Literature evidence | Roots of Daphne gnidium L. inhibit cell proliferation and induce apoptosis in the human breast cancer cell line MCF-7. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hexane extract, Dichloromethane extract, Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Daphne gnidium | |
| Geographical availability | Albania, Algeria, Baleares, Canary Is., Corse, France, Greece, Italy, Morocco, Portugal, Sardegna, Sicilia, Spain, Tunisia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | COX-2 | |
| Gene or Protein evidence | A low dose seemed to inhibit COX-2 activity whereas a high dose seemed to increase it. | |
| Target pathways | NA | |
| IC50 | Hexane - 630 +/- 16 μg/ml against MCF-7 Dichloromethane - 112 +/- 7 μg/ml against MCF-7 Ethyl acetate extracts - 263 +/- 9 μg/ml against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Surprisingly, we observed that activation of the inducible cyclooxygenase-2 followed the kinetics of apoptosis development. On the other hand, the dichloromethane extract showed a distinct effect on COX-2 activity as a function of the used dose. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:831233-1 | |
| Safety | NA |