| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1569 | |
| Phytochemical name or plant extracts | Danshen | |
| PMID | 17016654 | |
| Literature evidence | A primary interest of this laboratory is to obtain experimental evidence that supports the fundamental mechanistic theme for the combinatorial herbal strategy described above and its potential application in preventing and treating breast cancer (BCa). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Salvia miltiorrhizae Binge | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Leukemia, Pancreatic cancer, Head and neck squamous cancer | |
| Target gene or protein | AKT, p27, Rb, Cyclin D1, p53, p65, p50, NF-kB, HER2 | |
| Gene or Protein evidence | Danshen treatment induced the down-regulation of Akt phosphorylation and an increase in p27 in MCF-7 vec and MCF-7 HER2 cells. In addition, treatment with Danshen alone resulted in a pronounced reduction in the expression of Rb, cyclin D1, and p53, and also led to a diminution of p65 and p50 forms of NF-kappaB. HER2 expression was shown to confer resistance to Danshen-induced inhibition of proliferation and cell cycle delay, suggesting that HER2 is responsible for the resistance to Danshen. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken together, our results are consistent with the interpretation that interaction exists between Danshen and I'm-Yunity and that I'm-Yunity-Plus may have efficacy in the treatment of BCa, particularly for patients with ER+ status. | |
| Cell line/ mice model | MCF-7, MCF-7 vec cells and MCF-7 HER2 cells | |
| Additional information | Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines. Flow cytometric analysis showed that I'm-Yunity-Plus induced partial block of G1/S transition in MCF-7 cells, whereas Danshen slowed down cell progression from G1/S into G2/M phases of the cell cycle. | |
| PubChem ID | NA | |
| Additional PMIDs | 17016654 19610045 28459519 26018796 30208247 31726654 19885617 18698495 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456707-1 | |
| Safety | NA |