| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-165 | |
| Phytochemical name or plant extracts | Dandelion extract | |
| PMID | 31728288 | |
| Literature evidence | Dendrigraft poly-L-lysines (DGLs) which can induce tumor autophagy as mimics of natural abnormal proteins are crosslinked via a mild-acid-responsive linker (1,6-bis(4-formylbenzoyloxy) hexane). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Taraxacum mongolicum | |
| Geographical availability | Altay, Amur, Buryatiya, China North-Central, China South-Central, China Southeast, Chita, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Mongolia, Primorye, Qinghai, Taiwan, Tibet, Tuva, Yakutskiya | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | pS2, PR | |
| Gene or Protein evidence | DEE significantly induced the expression of estrogen related genes such as pS2 and PR, which was inhibited by tamoxifen at 1 μmol·L(-1). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The results demonstrate the potential estrogenic activities of DEE, providing scientific evidence supporting their use in traditional medicine | |
| Cell line/ mice model | MCF-7, immature rat uterotrophic assay | |
| Additional information | In addition, immature rat uterotrophic assay was carried out to identify estrogenic activity of DEE in vivo. The lowest concentration of DEE slightly increased the uterine wet weight, but there was no significant effect with the highest concentration of DEE. | |
| PubChem ID | NA | |
| Additional PMIDs | 26614455 20849941 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:254031-1 | |
| Safety | NA |