| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-641 | |
| Phytochemical name or plant extracts | Daidzein | |
| PMID | 10945618 | |
| Literature evidence | Soybeans contain a significant amount of the isoflavones daidzein and genistein, which are weak estrogens. | |
| IUPAC name | 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Glycine max | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Hainan, Inner Mongolia, Japan, Khabarovsk, Korea, Laos, Manchuria, Nansei-shoto, Primorye, Qinghai, Taiwan, Thailand, Tibet, Vietnam, Xinjiang | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Bone cancer | |
| Target gene or protein | BRCA1 ,BRCA2, VEGF-A, CXCL16, CDK1 , Cyclins A, Cyclin B, Cyclin D, CDK2, CDK4, p21(Cip1), p57(Kip2), caspase 9, ERα, c‑erbB‑2, AKR1BI, HRAS, GSTP1, p53, pS2, jun, GADD45, BAX, TNF, Rb1, p300 | |
| Gene or Protein evidence | Daidzein treatment resulted in decreases in cyclin D, CDK2, and CDK4, whereas the expression of CDK6 and cyclin E was unchanged, genistein and daidzein might contribute to regulation of the BRCA1 and BRCA2. In MCF-7 cells, low, stimulatory concentrations of test compounds determined the increase of CXCL16 and VEGF-A level. Daidzein treatment increased the expression of the CDK inhibitors p21(Cip1) and p57(Kip2), but not that of p27(Kip1). As another biomarker of apoptosis induction, caspase-9 activity was significantly increased by daidzein in both cells. In addition, ERα and c‑erbB‑2 expression was reduced by daidzein and genistein in both SK‑BR‑3 and ZR‑75‑1 cells in a dose‑dependent manner. Gene and protein expression studies show down-regulation of AKR1BI, HRAS and GSTP1 by the extracts. Conversely, p53, pS2, jun, GADD45 (P,0.001), BAX, TNF, Rb1 and p300 (P,0.05) mRNAs were significantly decreased in comparison with the control in the presence of daidzein. | |
| Target pathways | PI3K/Akt pathway | |
| IC50 | NA | |
| Potency | The results showed that genistein and daidzein potently trigger transactivation with ERbeta1 from estrogen response element-reporter genes (EC50s of 1.7-16 nM) although they were 400- to 600-fold less potent than 17beta-estradiol (E2) (EC50 of 0.02-0.04 nM). However, only genistein and daidzein inhibited constitutively active NF-kappaB and AP-1 and suppressed secretion of uPA from breast cancer cells. | |
| Cell line/ mice model | MCF-7, MDA MB-231, PC12, MCF10a, T47D, G-292, SKBR-3, HS578T, ZR‑75‑1 , MMTV-neu, MDA-MB-453 | |
| Additional information | Increase in Akt and FAK phosphorylation (in nonmetastatic ER-positive T47D cells and metastatic ER-negative MDA-MB-231 cells) Reduction of ERα and c‑erbB‑2 expression (in SK‑BR‑3 and ZR‑75‑1 cells ) | |
| PubChem ID | 5281708 | |
| Additional PMIDs | 12421874 15069695 12725655 16506217 21783746 17266178 18541420 19065587 23337939 34209224 10802284 18313242 16773531 20460823 22016638 21615235 23095751 25826638 26499209 27340792 28644496 28969363 28720470 30722112 11525599 10956151 10923837 17658826 34946514 22583409 24058373 11812927 15070945 15492830 16248551 17157887 17032659 17933522 18316793 18444135 18479682 19918100 20661825 20164315 20707345 21828252 24461312 24019393 26179608 26573593 27227510 29051735 28396216 29496164 1314077 8910911 9168894 9616286 8896889 10566643 10993028 11509969 10945618 23982890 12368416 12881020 15111739 15735101 16469160 16898868 19013426 19221874 19159489 20517637 23568763 24200780 24724627 29204990 31408695 32884687 34413161 25934515 11566575 22339411 17142977 14556117 10601582 8545857 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60450240-2 | |
| Safety | NA |