| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-27 | |
| Phytochemical name or plant extracts | D Rhamnose β-hederin (DRβ-H) | |
| PMID | 29146183 | |
| Literature evidence | An active triterpenoid saponin D Rhamnose β-hederin (DRβ-H) from Clematis ganpiniana, has been known induce the apoptosis of breast cancer cells, but the effect of DRβ-H on the metastasis of breast cancer cells is largely unknown. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid saponin | |
| Source of phytochemicals or plant Extracts | Clematis ganpiniana | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Tibet | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Apaf-1, cyt-c, Caspase 3, Caspase 9, miR-16, miR-23a, miR-24, miR-26a, miR-27a | |
| Gene or Protein evidence | Moreover, DRβ-H regulated the ratio of pro-apoptotic and anti-apoptotic Bcl-2 family proteins. Furthermore, DRβ-H induced depolarization of mitochondrial membrane potential which released Apaf-1 and Cytochrome C from the inter membrane space into the cytosol, where they promoted caspase-9 and caspase-3 activation. We also found that DRβ-H could decrease the expressions of several most abundant miRNAs (miR-16, miR-23a, miR-24, miR-26a, and miR-27a) transported by D/exo. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | This is the first report on the pro-apoptotic effects of DRβ-H, a novel oleanane-type triterpenoid saponin, on breast cancer cells and its comprehensive apoptosis pathways. It implied that oleanane-type triterpenoid saponin DRβ-H could be a promising candidate for chemotherapy of breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MCF-7/Doc, MCF-7/S | |
| Additional information | Our results suggested that DRβ-H could reduce D/exo secretion from MCF-7/Doc cells and induce the reduction in resistance transmission via D/exo. These results suggest that DRβ-H might be a potential therapeutic candidate for the treatment of breast cancer metastasis. | |
| PubChem ID | NA | |
| Additional PMIDs | 30250584 30061173 29146183 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1016980-1 | |
| Safety | NA |