| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1715 | |
| Phytochemical name or plant extracts | Cystoseira crinita extract | |
| PMID | 32406258 | |
| Literature evidence | Brown algae earned importance by virtue of their promising secondary metabolites of reasonable biological activities. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Cystoseira crinita | |
| Geographical availability | Egypt | |
| Plant parts | Sea weed | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax, Beclin-2 | |
| Gene or Protein evidence | Increased mRNA and protein expression of Bax and Beclin-1 as well as the decreased expression of Bcl-2 revealed the ability of both extracts to induce apoptosis and autophagy in MCF-7 cells. | |
| Target pathways | NA | |
| IC50 | 18.0 ± 0.74 µg/ml against MCF-7 | |
| Potency | Interestingly, employing MTT assay revealed cytotoxic effects of both extracts against a panel of cancer cells, where CCME showed a strong cytotoxic activity against MCF-7 cells (IC50 = 18.0 ± 0.74 µg/ml), while SHAE exhibited a moderate effect (IC50 = 31.1 ± 1.04 µg/ml). | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Both SHAE and CCME exhibited comparable DPPH (124.5 vs 125.6 µg/ml) and ABTS (257.1 vs 254.8 µg/ml) scavenging activities, respectively. Moreover, both crude extracts exhibited antimicrobial activity against various pathogenic microorganisms. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |