Phytochemical Name : Cyperus rotundus extract (EECR)

Properties Information
PhytoCAT-ID PhytoCAT-1092
Phytochemical name or plant extracts Cyperus rotundus extract (EECR)
PMID 31123166
Literature evidence The present results demonstrated that EECR has potential effects on inhibits the proliferation and induction apoptosis in TNBC.
IUPAC name NA
Phytochemicals’ class or type of plant extracts Ethanolic extract
Source of phytochemicals or plant Extracts Cyperus rotundus
Geographical availability Afghanistan, Albania, Aldabra, Algeria, Andaman Is., Angola, Assam, Austria, Azores, Baleares, Bangladesh, Benin, Borneo, Botswana, Bulgaria, Burkina, Burundi, Cambodia, Cameroon, Canary Is., Cape Provinces, Cape Verde, Caprivi Strip, Caroline Is., Central African Repu, Chad, Chagos Archipelago, China North-Central, China South-Central, China Southeast, Comoros, Congo, Corse, Cyprus, Djibouti, East Aegean Is., East Himalaya, Egypt, Equatorial Guinea, Eritrea, Ethiopia, France, Free State, Gabon, Gambia, Ghana, Greece, Guinea, Gulf of Guinea Is., Gulf States, Hainan, Hawaii, India, Iran, Iraq, Italy, Ivory Coast, Japan, Jawa, Kazakhstan, Kazan-retto, Kenya, Kirgizstan, Korea, Kriti, KwaZulu-Natal, Lebanon-Syria, Lesotho, Lesser Sunda Is., Libya, Madagascar, Madeira, Malawi, Malaya, Mali, Maluku, Manchuria, Marianas, Marshall Is., Mauritania, Mauritius, Morocco, Mozambique, Mozambique Channel I, Myanmar, Namibia, Nansei-shoto, Nepal, New South Wales, Nicobar Is., Niger, Nigeria, North Caucasus, Northern Provinces, Northern Territory, Ogasawara-shoto, Oman, Pakistan, Palestine, Philippines, Portugal, Queensland, Rodrigues, Romania, Rwanda, Réunion, Sardegna, Saudi Arabia, Selvagens, Senegal, Seychelles, Sicilia, Sierra Leone, Sinai, Socotra, Somalia, South Australia, South China Sea, Spain, Sri Lanka, St.Helena, Sudan, Sulawesi, Sumatera, Swaziland, Switzerland, Tadzhikistan, Taiwan, Tanzania, Thailand, Tibet, Togo, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Turks-Caicos Is., Uganda, Uzbekistan, Vanuatu, Vietnam, Wake I., West Himalaya, Western Australia, Western Sahara, Yemen, Yugoslavia, Zambia, Zaïre, Zimbabwe
Plant parts Rhizome
Other cancers Breast cancer
Target gene or protein Bcl-2, Bax
Gene or Protein evidence It induces apoptosis by promoting the expression of BAX and inhibiting the expression of BCL-2.
Target pathways It suggested that EECR may induce apoptosis through mitochondrial-associated apoptotic pathway in TNBC cells.
IC50 NA
Potency The present results demonstrated that EECR has potential effects on inhibits the proliferation and induction apoptosis in TNBC.
Cell line/ mice model MDA-MB-231, MDA-MB-468
Additional information  In addition, autophagy inhibitor 3-Methyladenine (3-MA) inhibited TNBC cells pro-survival autophagy and increased the sensitivity of EECR.
PubChem ID NA
Additional PMIDs NA
Additional sources of information https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:305797-1
Safety NA