| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1279 | |
| Phytochemical name or plant extracts | Cymarin | |
| PMID | 26610451 | |
| Literature evidence | Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3). | |
| IUPAC name | (3S,5S,8R,9S,10S,13R,14S,17R)-5,14-dihydroxy-3-[(2R,4S,5R,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde | |
| Phytochemicals’ class or type of plant extracts | Monoterpenoid | |
| Source of phytochemicals or plant Extracts | Adonis multiflora Nishikawa & Koki Ito | |
| Geographical availability | Japan, Korea | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Colon cancer, Liver cancer, Lung cancer, Ovarian cancer, Skin cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 5.10 ± 0.87µM against SKBR-3 | |
| Potency | These findings suggest that A. multiflora may have potential be a useful therapeutic natural source for cancer prevention. | |
| Cell line/ mice model | HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SKBR-3 | |
| Additional information | Shows significant cytotoxicity against HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3 cell lines | |
| PubChem ID | 441853 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:936942-1 | |
| Safety | Show acute toxicity, as given in pubchem |