| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-266 | |
| Phytochemical name or plant extracts | Cyclovirobuxine D (CVB-D) | |
| PMID | 24758922 | |
| Literature evidence | In this study, we reported that cyclovirobuxine D (CVB-D), an alkaloid component in a traditional Chinese herb, could induce autophagy in the MCF-7 human breast cancer cell line. | |
| IUPAC name | (1S,3R,6S,8R,11S,12S,14R,15S,16R)-7,7,12,16-tetramethyl-6-(methylamino)-15-[(1S)-1-(methylamino)ethyl]pentacyclo[9.7.0.01,3.03,8.012,16]octadecan-14-ol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Buxus microphylla | |
| Geographical availability | Japan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | LC3-I, LC3-II, ATG5 | |
| Gene or Protein evidence | Western blot analysis revealed that CVB-D significantly promoted the conversion from LC3-I to LC3-II and the expression of autophagy-related protein 5 (ATG5), which are both essential for autophagosome formation. | |
| Target pathways | Akt/mTOR pathway | |
| IC50 | 10 ± 2.51 μM against MCF-7 | |
| Potency | These findings shed new light on the pharmacological actions and mechanism of CVB-D and may support the potential utility of autophagy inducers in cancer treatment. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | After CVB-D treatment, a clear accumulation of autophagosomes was observed accompanied with elevated LC3 fluorescent puncta. | |
| PubChem ID | 260439 | |
| Additional PMIDs | 32319595 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:340303-1 | |
| Safety | Acute toxicity in pubchem |