| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-433 | |
| Phytochemical name or plant extracts | Cyclopia genistoides extract | |
| PMID | 17461595 | |
| Literature evidence | Evaluation of the phytoestrogenic activity of Cyclopia genistoides (honeybush) methanol extracts and relevant polyphenols. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Cyclopia genistoides | |
| Geographical availability | Cape Provinces | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results clearly show that C. genistoides methanol extracts display phytoestrogenic activity and act predominantly via ERbeta. | |
| Cell line/ mice model | MCF-7-BUS, MDA-MB-231 | |
| Additional information | All extracts transactivated ERE-containing promoter reporters via ERbeta but not via ERalpha. All extracts, except P122, caused proliferation of the estrogen-sensitive MCF-7-BUS cells. Proliferation of MCF-7-BUS cells was ER-dependent as ICI 182,780 reversed proliferation. Physiologically more relevant, extracts antagonized E2-induced MCF-7-BUS cell proliferation. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:489293-1 | |
| Safety | NA |