| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-151 | |
| Phytochemical name or plant extracts | Cyanidin-3-glucoside (Cy-3-gluc) | |
| PMID | 20170107 | |
| Literature evidence | However, the anthocyanin Cy-3-gluc was able to induce a downregulation of ER levels although with no significant effect on MCF-7 proliferation. | |
| IUPAC name | (2S,3R,4S,5S,6R)-2-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromenylium-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Puya laxa | |
| Geographical availability | Bolivia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ErbB2, Sirt1, KLF4, HER2, AKT, EMT | |
| Gene or Protein evidence | C3G attenuated ethanol-induced migration/invasion of breast cancer cells expressing high levels of ErbB2 (BT474, MDA-MB231 and MCF7(ErbB2)) in a concentration dependent manner, Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells. Cy3G is a potential anticancer reagent as it can inhibit EMT and breast cancer cell migration and invasion by upregulating KLF4. They inhibit the phospho-HER2 and phospho-AKT and were confirmed to induce HER2-psotive breast cancer cells apoptosis both in vitro and in vivo. | |
| Target pathways | STAT3/VEGF pathway | |
| IC50 | 1.8±0.5 µM against BT-474 2.6±0.8 µM against HCC1569 1.5±0.3 µM against MDA-MB-453 | |
| Potency | It is therefore suggested that flavonoids from LFP might be potentially useful components for functional foods and/or anti-breast cancer drugs Western blotting show that both peonidin-3-glucoside and cyanidin-3-glucoside significantly reduce the phospho-HER2, phospho-AKTs, and phopspho-p44/42MAPK levels compared to control cells | |
| Cell line/ mice model | MCF-7, BT-474, HCC1569, MDA-MB-453, 6–7-week-old female nude mice | |
| Additional information | Induces a downregulation of ER levels. C3G could also inhibit certain malignant behaviors of cancer cells, however, whether repression of EMT was involved in its anti-cancer especially TNBC effect remains unknown. Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2. | |
| PubChem ID | 441667 | |
| Additional PMIDs | 30251280 17851420 21034468 33240028 30876970 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:214615-2 | |
| Safety | NA |