| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1369 | |
| Phytochemical name or plant extracts | Cuscuta chinensis extract | |
| PMID | 34046322 | |
| Literature evidence | CONCLUSION: Our findings suggest that C. chinensis extract is able to inhibit proliferation and induce apoptosis in PC3 and MCF7 cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Chloroformic extract, Hydroalcoholic extract | |
| Source of phytochemicals or plant Extracts | Cuscuta chinensis | |
| Geographical availability | Afghanistan, Arizona, Assam, Bangladesh, China North-Central, China South-Central, China Southeast, Eritrea, Ethiopia, Ghana, India, Inner Mongolia, Iran, Iraq, Japan, Kazakhstan, Kirgizstan, Korea, Madagascar, Manchuria, Mexico Central, Mexico Northeast, Mexico Northwest, Mexico Southwest, Mongolia, Nansei-shoto, New Mexico, New South Wales, Northern Territory, Pakistan, Primorye, Qinghai, Queensland, Saudi Arabia, Socotra, Sri Lanka, Sudan, Tadzhikistan, Taiwan, Texas, Thailand, Tibet, Turkmenistan, Utah, Uzbekistan, Vietnam, West Himalaya, Western Australia, Xinjiang | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Prostate cancer , Colorectal cancer, Cervical cancer | |
| Target gene or protein | Bax, Bcl-2 , Caspase 3, PTEN | |
| Gene or Protein evidence | The gene expression of BAX/Bcl2 ratio, Caspase3 and PTEN increased in C. chinensis-treated cells compared to the control group. | |
| Target pathways | Intrinsic or mitochondrial pathway | |
| IC50 | At 24h, 48h: 400 µg/ml, 200 µg/ml against MCF-7 respectively Chloroform extract - 25 µg/ml against MDA-MB-468 Hydroalcoholic extract - 95 µg/ml against MDA-MB-468 | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-468, MCF-7, HT29, Hela, PC3, T47D | |
| Additional information | In conclusion, our results indicate that C. chinensis extract has cytotoxic activity in cancerous cells (PC3 and MCF7). The apoptosis leads to the upregulation of BAX/Bcl2, CASPASE3 and PTEN, and activation of lactate dehydrogenase. | |
| PubChem ID | NA | |
| Additional PMIDs | 15095143 25657780 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:267360-1 | |
| Safety | NA |