| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1458 | |
| Phytochemical name or plant extracts | Curcumol | |
| PMID | 32953746 | |
| Literature evidence | RESULTS: In the study, the administration of curcumol alone had no significant effects on the TNBC cells. | |
| IUPAC name | (1S,2S,5S,8R,9S)-2-methyl-6-methylidene-9-propan-2-yl-11-oxatricyclo[6.2.1.01,5]undecan-8-ol | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Curcuma wenyujin | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, India, Myanmar, Nepal, Sri Lanka, Thailand, Tibet, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Stomach cancer | |
| Target gene or protein | Bcl-2, Bak, IDH1, PUMA, p73 | |
| Gene or Protein evidence | Curcumol treatment also resulted in the suppression of xenograft growth in vivo (100 or 200 µg/kg for 21 days), as well as G1 phase arrest and an apoptotic response, which were accompanied by the upregulation of p73 expression and the activation of the expression of p53 upregulated modulator of apoptosis (PUMA) and Bcl-2 antagonistic killer (Bak). Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1. | |
| Target pathways | Triggers p53-independent apoptosis, which may be mediated by the p73-PUMA/Bak signaling pathway (MDA-MB-231) Modulates the YAP1/Skp2 molecular pathway Combination of curcumol and metformin causes activation of Wnt2/α-Catenin signaling pathway and suppression of EMT marker expression (IN VIVO) | |
| IC50 | At 48h, 72h: 240.7±85.0 µg/ml, 100.2±13.5 µg/ml against MDA-MB-231 respectively | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468, MGC-803 | |
| Additional information | Causes suppression of xenograft growth in vivo (100 or 200 µg/kg for 21 days) Attenuates anoikis resistance and metastasis in TNBC cells Reverses TNBC cell proliferation, migration, invasion, and EMT induced by rucaparib Triggers cell cycle arrest at the G2 phase, blocks the activity of MMP9 and downregulates of N-cadherin, Vimentin, Snail1, and Snail2 and upregulation of E-cadherin (MDA-MB-231 and MDA-MB-468) Causes arrest of cell cycle in the G2/M phase, increases the level of reactive oxygen species (ROS), decreases the mitochondrial membrane potential (MMP) and causes downregulation of isocitrate dehydrogenase 1 (IDH1) (MGC-803) | |
| PubChem ID | 14240392 | |
| Additional PMIDs | 28693277 32988876 30901274 29039582 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1009084-1 | |
| Safety | NA |