| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1416 | |
| Phytochemical name or plant extracts | Curcuma zedoaria extract | |
| PMID | 24883070 | |
| Literature evidence | Petroleum ether extracts of Curcuma zedoaria as well as Epirubicin produce a significant G0/G1 cell cycle arrest. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Petroleum ether extract | |
| Source of phytochemicals or plant Extracts | Curcuma zedoaria | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, India, Myanmar, Nepal, Sri Lanka, Thailand, Tibet, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer, Colorectal cancer | |
| Target gene or protein | E-cadherin, SDF-1, CXCR4, CCR7, CYP3A4, PXR, MDR1, BCRP | |
| Gene or Protein evidence | The level of expression of proteins E-cadherin and E-cadherin mRNA was significantly increased, while proteins SDF-1, CCR7, and CXCR4 mRNA were decreased after being incubated with petroleum ether extracts of Curcuma zedoaria at the concentrations of 300 µg/mL than control. PECZ significantly inhibited the expression of pregnane X receptor (PXR), multidrug resistance 1 (MDR1), breast cancer resistance protein (BCRP), and cytochrome P-450 (CYP3A4) in MDA-MB-231/docetaxel cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, Ca Ski, TNBC xenograft mice model,HCT-116 | |
| Additional information | Produces a significant G0/G1 cell cycle arrest causing inhibition of MDA-MB-231 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 34733941 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:796426-1 | |
| Safety | NA |