| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1133 | |
| Phytochemical name or plant extracts | Cudraxanthone I | |
| PMID | 24075210 | |
| Literature evidence | Flow cytometry was used for cell cycle analysis and detection of apoptotic cells, analysis of mitochondrial membrane potential (MMP) as well as measurement of reactive oxygen species (ROS). | |
| IUPAC name | 6,9-dihydroxy-3,3-dimethyl-8-(3-methylbut-2-enyl)pyrano[2,3-c]xanthen-7-one | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Maclura cochinchinensis | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, Christmas I., East Himalaya, Hainan, Japan, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nansei-shoto, Nepal, New Caledonia, New Guinea, New South Wales, Nicobar Is., Philippines, Queensland, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Tibet, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 7, Caspase 8, Caspase 9 | |
| Gene or Protein evidence | Compounds 3 arrested the cell cycle between G0/G1 and S phases, strongly induced apoptosis via caspases 3/7, caspase 8, caspase 9 activation and disrupted the MMP in CCRF-CEM cells. | |
| Target pathways | NA | |
| IC50 | 2.78 ± 0.19 μM against MDA-MB231 BCRP | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 BCRP | |
| Additional information | The cytotoxicity of the studied xanthones and especially compound 3 deserve more detailed exploration in the future to develop novel anticancer drugs against sensitive and otherwise drug-resistant phenotypes. | |
| PubChem ID | 86276176 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:584314-1 | |
| Safety | NA |