| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-608 | |
| Phytochemical name or plant extracts | Cudraticusxanthone A | |
| PMID | 27586822 | |
| Literature evidence | CONCLUSIONS: Collectively, these results indicate that CTXA possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Xanthone | |
| Source of phytochemicals or plant Extracts | Cudrania tricuspidata | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Korea, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP9, IκBα | |
| Gene or Protein evidence | Moreover, CTXA effectively blocked breast cancer cell migration and invasion. CTXA decreased the expression of matrix metalloproteinase-9, extracellular regulated kinases 1 and 2 and phosphorylation of the inhibitor IκBα in the MCF-7 and MDA-MB-231 cell lines. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Collectively, these results indicate that CTXA possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of breast cancer. | |
| Cell line/ mice model | MCF-7 cells, MDA-MB-231 | |
| Additional information | The results show that CTXA gradually reduced viability of the two breast cancer cell lines and induced apoptosis in a concentration-dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:582981-1 | |
| Safety | NA |