| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-504 | |
| Phytochemical name or plant extracts | Cucurbitacin E | |
| PMID | 25072848 | |
| Literature evidence | Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics. | |
| IUPAC name | [(E,6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Hemsleya delavayi | |
| Geographical availability | China South-Central | |
| Plant parts | Tubers | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, Survivin, XIAP, Bcl-2, Mcl-1, JNK, AKT, ERK | |
| Gene or Protein evidence | CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. | |
| Target pathways | NA | |
| IC50 | 0.05 nM against MCF-7 0.02 nM against MDA-MB-468 0.03 nM against MDA-MB-2311 CuE inhibited the growth of all five TNBC lines in a dose-dependent manner, with the IC50 being about 10–70 nM | |
| Potency | Overall, the MDA-MB-468 line appeared to be the most sensitive TNBC cell line in regards to the effects of CuE | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468, SW527, MCF-7 | |
| Additional information | Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics. | |
| PubChem ID | 5281319 | |
| Additional PMIDs | 31132750 25970614 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:50923178-1 | |
| Safety | NA |