| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-200 | |
| Phytochemical name or plant extracts | Cucurbitacin B | |
| PMID | 21866566 | |
| Literature evidence | Our data suggest that cucurbitacin B may in part induce apoptosis and exert growth inhibitory effect via interruption the Wnt signaling. | |
| IUPAC name | [(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Trichosanthes cucumerina | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, China Southeast, East Himalaya, India, Jawa, Laccadive Is., Lesser Sunda Is., Maldives, Myanmar, Nepal, Northern Territory, Pakistan, Philippines, Queensland, Sri Lanka, Sulawesi, Thailand, Vietnam, West Himalaya, Western Australia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, C-myc, β-catenin, F-actin, Vimentin, FAK, vinculin | |
| Gene or Protein evidence | Cyclin D1, c-Myc and β-catenin expression levels were reduced. Western blot analysis showed increased PARP cleavage and decreased Wnt-associated signaling molecules β-catenin, galectin-3, cyclin D1 and c-Myc, and corresponding changes in phosphorylated GSK-3β levels. Further studies have found that CuB downregulated the expression of F-actin/vimentin/FAK/vinculin in breast cancer cells, altering the distribution and reorganization of cytoskeletal proteins in the cells. | |
| Target pathways | RAC1/CDC42/RhoA signaling Wnt signaling pathway | |
| IC50 | 4.60 µg/ml against SKBR-3 88.75 µg/ml against MCF-7 | |
| Potency | In summary, our data indicate that cucurbitacin B targeting of the Wnt signaling pathway could be an innovative approach for breast cancer treatment. | |
| Cell line/ mice model | SKBR-3, MCF-7 | |
| Additional information | NA | |
| PubChem ID | 5281316 | |
| Additional PMIDs | 23062075 30548720 29425586 26018422 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:294175-1 | |
| Safety | acute toxic in pubchem database |