| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-409 | |
| Phytochemical name or plant extracts | Cryptotanshinone | |
| PMID | 30208247 | |
| Literature evidence | All these findings suggest that Dsh-003 inhibit human HCC cell lines and could potentially be used as a novel drug for HCC treatment. © 2018 Wiley Periodicals, Inc. | |
| IUPAC name | (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g][1]benzofuran-10,11-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Salvia miltiorrhiza | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | p38/JNK, Erk1/2 | |
| Gene or Protein evidence | Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells. | |
| Target pathways | JAK2/STAT4/ perforin pathway | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | HepG2 , MCF-7, HA22T | |
| Additional information | Cryptotanshinone also evidenced sensitizing effects to a broad range of anti-cancer agents including Fas/Apo-1, TNF-α, cisplatin, etoposide or 5-FU through inducing ER stress, highlighting the therapeutic potential in the treatment of human hepatoma and breast cancer. | |
| PubChem ID | 160254 | |
| Additional PMIDs | 24761844 22490436 19827307 30208247 22113823 32922039 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456707-1 | |
| Safety | NA |