| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-690 | |
| Phytochemical name or plant extracts | Crude extract of piperine free P. nigrum | |
| PMID | 27155135 | |
| Literature evidence | These results suggest that PFPE can enhance breast cancer cell response to phytochemicals, then induce cell cycle arrest, and inhibit cancer cell proliferation resulting in tumor size decrease in the PFPE treated group. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Crude extract | |
| Source of phytochemicals or plant Extracts | Piper nigrum | |
| Geographical availability | India | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, ER, E-cadherin, MMP9, MMP2, c-Myc, VEGF, E-cadherine, c-Myc | |
| Gene or Protein evidence | PFPE was found to up-regulate p53, and down-regulate estrogen receptor (ER), E-cadherin (E-cad), matrix metalloproteinase 9 (MMP-9), matrix metalloproteinase 2 (MMP-2), c-Myc, and vascular endothelial growth factor (VEGF) levels in breast cancer rats. Moreover, PFPE decreased protein levels of E-cad, c-Myc, and VEGF in MCF-7 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results suggest that PFPE can enhance breast cancer cell response to phytochemicals, then induce cell cycle arrest, and inhibit cancer cell proliferation resulting in tumor size decrease in the PFPE treated group. | |
| Cell line/ mice model | mammary tumorigenesis rats and breast cancer cell lines MCF-7 and ZR-75-1. | |
| Additional information | It further suggests that PFPE may suppress tumor cell invasion, migration, and angiogenesis. In addition, PFPE possessed cancer prevention effects through generation of reactive oxygen species (ROS) to higher cancer cell cellular stress. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:682369-1 | |
| Safety | NA |