| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-276 | |
| Phytochemical name or plant extracts | Crokongendin B (2) | |
| PMID | 34236840 | |
| Literature evidence | All these results suggested that 6 may serve as a promising lead for the development of novel anti-TNBC agents in the future. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Croton kongensis | |
| Geographical availability | China South-Central, Hainan, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1.77 ± 0.185 μM against MDA-MB-231 0.842 ± 0.0953 μM against MDA-MB-468 1.24 ± 0.0601 μM against MCF-7 | |
| Potency | Most of the compounds (1, 2, and 6–23) exhibited potent cytotoxicity (IC50s < 3 μM) against all cell lines and were generally more effective on TNBC cells than on MCF-7. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468, MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:342785-1 | |
| Safety | NA |