| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-375 | |
| Phytochemical name or plant extracts | Crocin | |
| PMID | 26884946 | |
| Literature evidence | We found that Crocin can significantly inhibit the proliferation of MCF-7 cells, and induce their apoptosis through mitochondrial signaling pathways including the activation of Caspase-8, upregulation of Bax, the disruption of mitochondrial membrane potential (MMP), and the release of cytochrome c. | |
| IUPAC name | bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate | |
| Phytochemicals’ class or type of plant extracts | Terpenoid | |
| Source of phytochemicals or plant Extracts | Crocus sativus | |
| Geographical availability | Greece | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Colon cancer, Stomach cancer | |
| Target gene or protein | ERα, HDAC2 | |
| Gene or Protein evidence | Therefore, crocetin beta-d-glucosyl ester from Crocus sativus biowastes showed antiproliferative effect possibly by inhibiting estrogen receptor alpha and HDAC2 mediated signalling cascade. | |
| Target pathways | Wnt/β-Catenin Pathway | |
| IC50 | NA | |
| Potency | Therefore, we postulate that Crocin might have cancer-preventive and cancer-therapeutic benefit for human breast cancer. | |
| Cell line/ mice model | MKN-28, MCF-7, MDA-MB-231, Caco-2, BALB/c mice | |
| Additional information | Our findings suggest crocin as a promising complementary antimetastatic herbal medicine for treatment of TNBC. | |
| PubChem ID | 5281233 | |
| Additional PMIDs | 30351203 32127777 32731416 35240313 21936628 17352254 26884946 27039797 30341939 34263648 29747750 28322405 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:436688-1 | |
| Safety | NA |