| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-671 | |
| Phytochemical name or plant extracts | Crinum amabile extract | |
| PMID | 31097973 | |
| Literature evidence | Meanwhile, cell proliferation assay revealed that F5 fraction was able to inhibit normal cell proliferation as well as VEGF-induced cell proliferation of normal endothelial cell (HUVECs). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | F5 fraction of Chloroformic extract | |
| Source of phytochemicals or plant Extracts | Crinum amabile | |
| Geographical availability | India | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 116.66±7.99 μg/mL against MCF-7 169.92±6.12 μg/mL against MDA-MB-231 | |
| Potency | F5 fraction of CE demonstrated the highest cytostatic activities against all the human cancer cell lines tested with MCF-7, ER+ breast cancer cells being the most susceptible. Additionally, F5 fraction also showed a similar inhibition effect on MDA-MB-231, ER- breast cancer cells, suggesting that the cytostatic effect of F5 fraction was non-cell-specific. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HCT-116, HT-29 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:63772-1 | |
| Safety | NA |