| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1891 | |
| Phytochemical name or plant extracts | Cratoxy formosum extract | |
| PMID | 28343074 | |
| Literature evidence | In summary, CF leaf extract can inhibit cell proliferation, induce cell apoptosis, and reduce cell migration in the MCF-7 cell line. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Cratoxy formosum | |
| Geographical availability | NA | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Rac1, CDK6, p21, Cyclin D1, MMP2, MMP9 | |
| Gene or Protein evidence | In addition, the extract inhibited cancer cell migration at 25μg/mL by reducing MMP 2 and MMP 9 protein expression. Moreover, CF leaf extracts strongly decreased expression of the cell cycle regulatory protein Rac1 and downstream protein, cdk6. CF leaf extract significantly stimulated p21 and this correlated with a reduction in cyclin D1 protein levels. | |
| Target pathways | NA | |
| IC50 | At 24h and 48h: 85.70±4.52 μg/mL and 53.74±3.02 μg/mL against MCF-7 | |
| Potency | Moreover, CF significantly induced ROS formation, increased caspase 3 activities, and reduced the mitochondrial membrane potential, leading to cancer cell apoptosis and cell death. In addition, the extract inhibited cancer cell migration at 25μg/mL by reducing MMP 2 and MMP 9 protein expression. | |
| Cell line/ mice model | MCF - 7 | |
| Additional information | In summary, CF leaf extract can inhibit cell proliferation, induce cell apoptosis, and reduce cell migration in the MCF-7 cell line. It could also be beneficial for enhancing the activity of anticancer drugs used to treat breast cancer. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |