| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-175 | |
| Phytochemical name or plant extracts | Cranberry extract | |
| PMID | 15173424 | |
| Literature evidence | Using flow cytometric analyses of DNA distribution (cell cycle) and annexin V-positivity (apoptosis), Fr6 was shown in MDA-MB-435 cells to block cell cycle progression (P < 0.05) and induce cells to undergo apoptosis (P < 0.05) in a dose-dependent manner. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | 1% acetic acid:Methanol fraction | |
| Source of phytochemicals or plant Extracts | Vaccinium macrocarpon | |
| Geographical availability | Connecticut, Delaware, District of Columbia, Illinois, Indiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, New Brunswick, New Hampshire, New Jersey, New York, Newfoundland, North Carolina, Nova Scotia, Ohio, Ontario, Pennsylvania, Prince Edward I., Québec, Rhode I., Tennessee, Vermont, Virginia, West Virginia, Wisconsin | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 212 ± 50 mg/ml against MDA-MB-435 47 ± 22 mg/ml against MCF-7 | |
| Potency | Fr6 was shown in MDA-MB-435 cells to block cell cycle progression (P < 0.05) and induce cells to undergo apoptosis (P < 0.05) in a dose-dependent manner. Fr6 is potentially a source of a novel anticancer agent. | |
| Cell line/ mice model | MDA-MB-435, MCF-7 | |
| Additional information | The androgen-dependent prostate cell line LNCaP was the most sensitive of those tested (10 mg/L Fr6 inhibited its growth by 50%), and the estrogen-independent breast line MDA-MB-435 and the androgen-independent prostate line DU145 were the least sensitive (250 mg/L Fr6 inhibited their growth by 50%). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:261912-2 | |
| Safety | NA |