| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2060 | |
| Phytochemical name or plant extracts | Cotinus coggygria extract | |
| PMID | 27023497 | |
| Literature evidence | Although many of these compounds have interesting individual biological activities, their natural blends seem to exert specific effects on the proliferation of cell lines either growing adherent or in suspension, suggesting potential use in fighting cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Cotinus coggygria Scop. | |
| Geographical availability | Albania, Austria, Bulgaria, China North-Central, China South-Central, China Southeast, Czechoslovakia, East Himalaya, France, Greece, Hungary, Iran, Italy, Kazakhstan, Kriti, Krym, Lebanon-Syria, Nepal, North Caucasus, Pakistan, Romania, South European Russi, Switzerland, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, West Himalaya, Yugoslavia | |
| Plant parts | Branches and leaves | |
| Other cancers | Breast cancer, Lung cancer, Leukemia | |
| Target gene or protein | p27, p21 | |
| Gene or Protein evidence | Then, the addition of extract #57 does not cause any appreciable augment of p27 expression. In this case, it appears that, compared to controls, p21 is strongly expressed in MCF-7 cells, while no evident changes have been observed in A549 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Only the extracts of J. communis and C. coggygria showed marked cytotoxic effects, affecting both cell morphology and growth. A dose-dependent effect of these two extracts was also observed on the cell cycle distribution. Incubation of all the cell lines in a medium containing J. communis extract determined a remarkable accumulation of cells in the G2/M phase, whereas the C. coggygria extract induced a significant increase in the percentage of G1 cells. | |
| Cell line/ mice model | A549, MCF-7, TK6, U937 | |
| Additional information | The novelty of our findings stands on the observation that the two extracts, consistently, elicited coherent effects on the cell cycle in four cell lines, independently from their phenotype, as two of them have epithelial origin and grow adherent and two are lymphoblastoid and grow in suspension. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30088655-2 | |
| Safety | NA |