| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1049 | |
| Phytochemical name or plant extracts | Costunolide | |
| PMID | 22147197 | |
| Literature evidence | However, did not have the same effect on the intrinsic pathway as revealed by analysis of mitochondrial membrane potential (Δψm) with JC-1 dye and expression of Bcl2 and Bax proteins level. | |
| IUPAC name | (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Costus speciosus | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, New Guinea, Nicobar Is., Philippines, Queensland, Solomon Is., Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam, West Himalaya | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer, Skin cancer | |
| Target gene or protein | p21WAF1, Cdc2, Cyclin B1, Fas, Caspase 8, Caspase 3, Cyclin D1, Cyclin D3, CDK-4, CDK-6, p18 INK4c, p27 KIP1 | |
| Gene or Protein evidence | Furthermore, costunolide induced cell cycle arrest in the G2/M phase via decrease in Cdc2, cyclin B1 and increase in p21WAF1 expression, independent of p53 pathway in p53-mutant MDA-MB-231 cells and increases Cdc2-p21WAF1 binding. Costunolide induced apoptosis through the extrinsic pathway, including the activation of Fas, caspase-8, caspase-3, and degradation of PARP. Western blotting results confirmed the alterations in the expression of cell cycle regulators (cyclin D1, D3, CDK-4, CDK-6, p18 INK4c, p21 CIP1/Waf-1 and p27 KIP1) and apoptosis inducers (caspase-3 and caspase-9) upon costunolide treatment in comparison with their expressions in normal breast cell line (MCF-10A). | |
| Target pathways | c-Myc/p53 and AKT/14-3-3 pathway | |
| IC50 | 5.26+/-0.30 μg/mL against MCF-7 | |
| Potency | Through this study we confirm that costunolide induces G2/M cell cycle arrest and apoptotic cell death via extrinsic pathway in MDA-MB-231 cells suggesting that it could be a promising anticancer drug especially for ER-negative breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Costunolide has recently emerged as a potential anti-cancer agent in various types of cancer, including colon, lung, and breast cancer. Costunolide activated the p38 and c-Jun N-terminal kinase pathways while suppressing the extracellular signal-regulated kinase (ERK), STAT3, NF-κB, and Akt pathways in A431 cells. | |
| PubChem ID | 5281437 | |
| Additional PMIDs | 24733523 26178525 28117370 23997800 33669832 22147197 34490824 21072773 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:796383-1 | |
| Safety | NA |