| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-682 | |
| Phytochemical name or plant extracts | Corydalis saxicola Bunting total alkaloids (CSBTA) | |
| PMID | 33574755 | |
| Literature evidence | In this study, we aimed to verify whether CSBTA could relieve cancer induced bone pain and inhibit osteoclastogenesis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Corydalis saxicola | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | RANKL/OPG | |
| Gene or Protein evidence | Further in vitro analysis confirmed that CSBTA reduced the expression of RANKL and downregulate the level of RANKL/OPG ratio in breast cancer cells. | |
| Target pathways | NF-κB and c-Fos/NFATc1 pathways | |
| IC50 | NA | |
| Potency | Taken together, these in vivo results suggested that CSBTA could ameliorate this CIBP and bone lesion by inhibiting breast cancer cell-induced osteoclast formation and function. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Moreover, CSBTA could inhibit osteoclastogenesis by suppressing RANKL-induced NF-κB and c-Fos/NFATc1 pathways. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:672482-1 | |
| Safety | NA |