| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-565 | |
| Phytochemical name or plant extracts | Corosolic acid | |
| PMID | 29702597 | |
| Literature evidence | Furthermore, corosolic acid significantly induces reactive oxygen species (ROS) levels, but antioxidants (N-acetyl-l-cysteine (NAC) and trolox) do not inhibit corosolic acid-induced cell death. | |
| IUPAC name | (1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Lagerstroemia speciosa | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, East Himalaya, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Philippines, Sri Lanka, Sulawesi, Sumatera, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Kidney cancer, Liver cancer, Colon cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Therefore, our results suggest that corosolic acid induces non-apoptotic cell death in cancer cells through the increase of lipid peroxidation. All the compounds didn't show nocytotoxic activity against MCF-7 and A549 cell lines (IC₅₀>50 mg•L⁻¹). | |
| Cell line/ mice model | ACHN , A498, MDA-MB-231, SK-Hep1, Huh7, T47D, HT-29, K-562, MCF-7 | |
| Additional information | In addition, corosolic acid induces non-apoptotic cell death in other renal cancer (ACHN and A498), breast cancer (MDA-MB231), and hepatocellular carcinoma (SK-Hep1 and Huh7) cells, and &alpha,-tocopherol markedly inhibits corosolic acid-induced cell death. | |
| PubChem ID | 6918774 | |
| Additional PMIDs | 24459770 24060908 28905569 29702597 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:553618-1 | |
| Safety | NA |