| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-344 | |
| Phytochemical name or plant extracts | Corn silk extract | |
| PMID | 31781357 | |
| Literature evidence | Recently, plant-derived natural products gain attention as anticancer agents due to the nontoxic nature. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Zea mays | |
| Geographical availability | Guatemala, Mexico Central, Mexico Southwest | |
| Plant parts | Corn silk | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bax, Bcl-2, Caspase 3, Caspase 9 | |
| Gene or Protein evidence | The real-time PCR data showed a significant upregulation in p53, Bax, caspase-3, and caspase-9 and downregulation in the mRNA expression of Bcl-2 genes in MCF-7 cells exposed to CSE. | |
| Target pathways | ROS-Mediated Mitochondrial Pathway | |
| IC50 | NA | |
| Potency | Collectively, the data from this study stated that corn silk extract induced apoptosis via the ROS-mediated mitochondrial pathway in MCF-7 cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Our results showed that CSE decreased the cell viability and increased the apoptosis in a dose-dependent manner. The level of LPO and ROS production was found significantly higher, however, GSH and MMP level was observed lower in CSE-treated MCF-7 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 31781357 24056502 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:426810-1 | |
| Safety | NA |