| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1269 | |
| Phytochemical name or plant extracts | Coriolus versicolor extract | |
| PMID | 28412218 | |
| Literature evidence | ETHNOPHARMACOLOGICAL RELEVANCE: Coriolus versicolor (CV) is a mushroom traditionally used for strengthening the immune system and nowadays used as immunomodulatory adjuvant in anticancer therapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Coriolus versicolor | |
| Geographical availability | Temperate Asia, North America and Europe, including the UK | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Stomach cancer, Colorectal cancer | |
| Target gene or protein | p53, Bcl-2, IL-6, IL-8, MMP-9, TLR4, p-IκB | |
| Gene or Protein evidence | These results suggested that apoptosis induction, differentially dependent of p53 and Bcl-2 expressions, might be the possible mechanism of CV extract-mediated cytotoxicity in human breast cancer cells in vitro. The results showed that the CV extract inhibited IL-6, IL-8, and MMP-9 production by the LPS-stimulated cells. This effect was accompanied by a decrease in TLR4 and p-IκB expression. | |
| Target pathways | NA | |
| IC50 | 984 ± 24 µg/mL against MCF-7 | |
| Potency | The HUVEC cells were stimulated with a CV extract (100 µg/mL) and/or LPS (100 ng/mL) for 24 h, and the MCF-7 cells were treated with the CV extract (100 µg/mL) and/or LPS (20 µg/mL) for 48 h, respectively. | |
| Cell line/ mice model | HUVEC , MDA-MB-231, MCF-7 and T-47D, HL-60 cells. | |
| Additional information | Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. | |
| PubChem ID | NA | |
| Additional PMIDs | 15908782 33260615 18292947 | |
| Additional sources of information | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277906/ | |
| Safety | NA |