| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-86 | |
| Phytochemical name or plant extracts | Coriolic acid | |
| PMID | 33114669 | |
| Literature evidence | In our study, we targeted breast cancer stem cells (BCSCs) using a natural compound, coriolic acid, from Salicornia herbacea L. | |
| IUPAC name | (9Z,11E)-13-hydroxyoctadeca-9,11-dienoic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Salicornia herbacea | |
| Geographical availability | Belgium, Denmark, Finland, France, Germany, Great Britain, Ireland, Netherlands, Norway, Poland, Spain, Sweden | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Nanog,Oct4, CD44, c-Myc | |
| Gene or Protein evidence | It also decreased the subpopulation of CD44high/CD24 low cells, a cancer stem cell (CSC) phenotype, and specific genes related to CSCs, such as Nanog,Oct4, and CD44. Coriolic acid decreased the transcriptional and translational levels of the c-Myc gene, which is a CSC survival factor. | |
| Target pathways | NA | |
| IC50 | 289.3 µM against MDA-MB-231 386.9 µM against MCF-7 | |
| Potency | These results indicated that coriolic acid could be a novel compound to target BCSCs via regulation of c-Myc. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Coriolic acid inhibited the formation of mammospheres and induced BCSC apoptosis. It also decreased the subpopulation of CD44high/CD24low cells, a cancer stem cell (CSC) phenotype, and specific genes related to CSCs, such as Nanog,Oct4, and CD44. | |
| PubChem ID | 5282947 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:166520-1 | |
| Safety | NA |