| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1820 | |
| Phytochemical name or plant extracts | Coriandrum sativum extract | |
| PMID | 24517259 | |
| Literature evidence | The extract exhibited anticancer activity in MCF-7 cells by affecting antioxidant enzymes possibly leading to H2O2 accumulation, cell cycle arrest at the G2/M phase and apoptotic cell death by the death receptor and mitochondrial apoptotic pathways. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Coriandrum sativum | |
| Geographical availability | Afghanistan, Iran, Lebanon-Syria, North Caucasus, Pakistan, Palestine, Saudi Arabia, Sinai, Transcaucasus, Turkey | |
| Plant parts | Leaves, root, stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Catalase, Superoxide dismutase, Glutathione peroxidase, Caspase 3, Caspase 8, Caspase 9 | |
| Gene or Protein evidence | Activities of the antioxidant enzymes, catalase, superoxide dismutase, glutathione peroxidase, and of the caspases-3, -8 and -9 were assayed on treatment with the extract. | |
| Target pathways | The herb exhibited anticancer activity in MCF-7 breast cancer cells by affecting antioxidant enzymes leading to H2O2 accumulation, cell cycle arrest at the G2/M phase and apoptotic cell death by the death receptor and mitochondrial apoptotic pathways. | |
| IC50 | 200.0 ± 2.6 μg/ml against MCF-7 | |
| Potency | C. sativum root extract is able to inhibit H2O2-induced MCF7 cancer cell migration, indicating its potential in preventing metastasis. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:840760-1 | |
| Safety | NA |