| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1627 | |
| Phytochemical name or plant extracts | Cordyceps sinensis extract | |
| PMID | 32422358 | |
| Literature evidence | Extracts of Cordyceps sinensis inhibit breast cancer growth through promoting M1 macrophage polarization via NF-?B pathway activation. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Fungal extract | |
| Source of phytochemicals or plant Extracts | Cordyceps sinensis | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NF-κB pathway | |
| IC50 | NA | |
| Potency | These findings suggest that Cordyceps sinensis could potently suppress TNBC progression by promoting M1 phenotypic differentiation of macrophages via activation NF-κB signaling pathway in tumor microenvironment. | |
| Cell line/ mice model | orthotopic mouse tumor model 4T1 | |
| Additional information | In the orthotopic mouse tumor model, Cordyceps sinensis inhibited the 4T1 tumor growth in a dose dependent manner, and the immunohistochemical staining analysis showed that there is a positive correlation between tumor growth inhibition and macrophage M1-like polarized phenotype. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |