| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1727 | |
| Phytochemical name or plant extracts | Cordyceps militaris extract(AECM) | |
| PMID | 19131705 | |
| Literature evidence | AECM increased hyperpolarization of mitochondrial membrane potential and promoted the activation of caspases. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Cordyceps militaris | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, AKT | |
| Gene or Protein evidence | The results indicated that AECM-induced apoptosis may relate to the activation of caspase-3 and mitochondria dysfunctions that correlate with the inactivation of Akt. | |
| Target pathways | AECM-induced apoptosis was associated with the inhibition of Akt activation in a time-dependent manner, and pretreatment with LY294002, a PI3K/Akt inhibitor, significantly increased AECM-induced apoptosis. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Both the cytotoxic effect and apoptotic characteristics induced by AECM treatment were significantly inhibited by z-DEVD-fmk, a caspase-3 inhibitor, which demonstrates the important role of caspase-3 in the observed cytotoxic effect. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |