| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1692 | |
| Phytochemical name or plant extracts | Cordycepin | |
| PMID | 31450828 | |
| Literature evidence | Consequently, the C. militaris concentrate and cordycepin exhibited significant anticancer effects through their ability to induce apoptosis in breast cancer cells. | |
| IUPAC name | (2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol | |
| Phytochemicals’ class or type of plant extracts | Nucleoside analog | |
| Source of phytochemicals or plant Extracts | Cordyceps militaris | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 9.58 µM against MCF-7 | |
| Potency | Cordycepin, a natural product isolated from the fungus Cordyceps militaris, is a potential candidate for breast cancer therapy. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Cordycepin regulates GSK-3β/β-catenin signaling in human leukemia cells. Cordycepin enhanced proteasome-dependent degradation and inhibited nuclear translocation of β-catenin in leukemia cells. | |
| PubChem ID | 6303 | |
| Additional PMIDs | 32606622 24086728 | |
| Additional sources of information | NA | |
| Safety | acute toxic in pubmed database |