| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1766 | |
| Phytochemical name or plant extracts | Coprinus comatus extract | |
| PMID | 22135900 | |
| Literature evidence | In addition, the data obtained showed that only ethyl acetate extract inhibited the activity of IKK complex, at close to 90% as compared to the control of the untreated sample. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Coprinus comatus | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Ikappaalpha | |
| Gene or Protein evidence | The Shaggy Inc Cap medicinal mushroom, Coprinus comatus (O.F.Mull.: Fr.) Pers. (Agaricomycetideae) substances interfere with H2O2 induction of the NF-kappaB pathway through inhibition of Ikappaalpha phosphorylation in MCF7 breast cancer cells | |
| Target pathways | NF-κB pathway | |
| IC50 | 76 µg/mL against MCF-7 | |
| Potency | These results suggest that C. comatus contains potent compounds capable of inhibiting NF-kappaB function and also possibly acts as an antitumor agent. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | This study illustrates the potential of the C comatus mushroom as a natural antiandrogenic modulator that could serve in the treatment of prostatic diseases. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |