| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1565 |
| Phytochemical name or plant extracts | Coprinellus sp. (CME) |
| PMID | 16391863 |
| Literature evidence | Water-based extracts of three mushroom species, Coprinellus sp., Coprinus comatus, Flammulina velutipes (CME, CCE and FVE, respectively), were identified as novel anti-breast cancer agents. |
| IUPAC name | NA |
| Phytochemicals’ class or type of plant extracts | Mushroom species/Aqueous extract |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | NA |
| Gene or Protein evidence | NA |
| Target pathways | NA |
| IC50 | 40 µg/ml against MDA-MB-231 |
| Potency | More interestingly, mushroom extracts CME and FVE induced an exceptionally rapid apoptosis on MCF-7 and MDA-MB-231 detected by Annexin V-FITC within 2 h of treatment and DNA fragment end-labeling assay (TUNEL) in 5 h of treatment. |
| Cell line/ mice model | MCF-7, MDA-MB-231, BT-20 |
| Additional information | These results suggest that mushroom species Coprinus comatus, Coprinellus sp. and Flammulina velutipes contain potent antitumor compounds for breast cancer. |
| PubChem ID | NA |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |