| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1393 | |
| Phytochemical name or plant extracts | Convallatoxin | |
| PMID | 24582402 | |
| Literature evidence | Five compounds (12, 16, 20, 22, and 31) showed significant cytotoxicity against all ten cancer cell lines, with notable potency at the ng/mL level against some cell lines, which merits further development as clinical trial candidates. | |
| IUPAC name | (3S,5S,8R,9S,10S,13R,14S,17R)-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde | |
| Phytochemicals’ class or type of plant extracts | Monoterpenoid | |
| Source of phytochemicals or plant Extracts | Antiaris toxicaria | |
| Geographical availability | Andaman Is., Angola, Benin, Bismarck Archipelago, Borneo, Burkina, Burundi, Cambodia, Cameroon, Central African Repu, Chad, China South-Central, China Southeast, Congo, Ethiopia, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Gulf of Guinea Is., Hainan, India, Ivory Coast, Jawa, Kenya, Laos, Lesser Sunda Is., Liberia, Madagascar, Malaya, Mali, Maluku, Myanmar, New Guinea, Nigeria, Northern Territory, Queensland, Rwanda, Santa Cruz Is., Senegal, Sierra Leone, Solomon Is., Sri Lanka, Sudan, Sulawesi, Sumatera, Tanzania, Thailand, Togo, Uganda, Vanuatu, Vietnam, Yemen, Zambia, Zaïre | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Squamous cell cancer, Lung cancer, Glioma, Prostate cancer, Ovarian cancer, Kidney cancer, Colon cancer, Skin cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.63 ± 0.56 µM against BT-474 0.69 ± 0.59 µM against MDA-MB-231 | |
| Potency | ED50 : 0.0065 µg/mL (MCF-7) | |
| Cell line/ mice model | KB, KB-VIN, A549, MCF-7, U-87-MG, PC-3, 1A9, CAKI-1, HCT-9, S-KMEL-2, HCT-116, SF-268, HL-60, BT-474, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 441852 | |
| Additional PMIDs | 30398120 22348979 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:850341-1 | |
| Safety | NA |