| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-899 | |
| Phytochemical name or plant extracts | Conferone | |
| PMID | 24860735 | |
| Literature evidence | Conferone, mogoltacin, and feselol from F. gummosa suppress P-gp-mediated drug efflux in highly resistant human breast cancer cells. | |
| IUPAC name | 7-[(2,5,5,8a-tetramethyl-6-oxo-4,4a,7,8-tetrahydro-1H-naphthalen-1-yl)methoxy]chromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Ferula gummosa | |
| Geographical availability | Iran, Turkmenistan | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Conferone, mogoltacin, and feselol from F. gummosa suppress P-gp-mediated drug efflux in highly resistant human breast cancer cells. | |
| Cell line/ mice model | MCF-7/Dox | |
| Additional information | At 25 μM, all the tested sesquiterpene coumarins restored at least 50% of the reference uptake (uptake by sensitive cells), but at 10 μM, their potency varied where conferone showed the highest potency and feselol showed the lowest potency. | |
| PubChem ID | 3108117 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:842298-1 | |
| Safety | NA |