| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1282 | |
| Phytochemical name or plant extracts | Condensed tannins | |
| PMID | 15670892 | |
| Literature evidence | The potential anti-angiogenic activities of water-soluble condensed tannins isolated from black beans were evaluated using HEL 299 normal human fibroblast lung cells, Caco-2 colon, MCF-7 and Hs578T breast, and DU 145 human prostatic cancer cells. | |
| IUPAC name | 2-(3,4-dihydroxyphenyl)-2-[[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl]oxy]-3,4-dihydrochromene-3,4,5,7-tetrol | |
| Phytochemicals’ class or type of plant extracts | Polyphenols | |
| Source of phytochemicals or plant Extracts | Phaseolus vulgaris | |
| Geographical availability | Costa Rica, Guatemala, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Colon cancer, Prostate cancer | |
| Target gene or protein | MMP2, MMP9, VEGF | |
| Gene or Protein evidence | After 24h exposure to Caco-2, MCF-7, Hs578T, and DU 145 cancer cells, water-soluble black bean condensed tannins at 24 microM suppressed fetal bovine serum stimulated cell migration, the secretion of matrix metalloproteinase-2 (MMP-2 or gelatinase A), matrix metalloproteinase-9 (MMP-9 or gelatinase B), and vascular endothelial growth factor VEGF(165) receptor expression by the cancer cells in the conditioned media. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | HEL 299, Caco-2, MCF-7, Hs578T, DU 145 | |
| Additional information | The secretion of pro-MMP-2 and pro-MMP-9 was measured as an indicator of the inhibitory activity of condensed tannins against Caco-2, MCF-7, Hs578T, and DU 145 cancer cells.MCF-7 and Hs578T breast cancer cells showed declined cell viability with increasing tannin concentration | |
| PubChem ID | 107876 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:514191-1 | |
| Safety | NA |