| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-195 | |
| Phytochemical name or plant extracts | Colocynth Extracts | |
| PMID | 28928657 | |
| Literature evidence | Furthermore, GC-MS/MS analysis revealed the presence of certain novel compounds in both the extracts that are responsible for the anti-cancer role of the extracts. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanol and acetone pulp extract | |
| Source of phytochemicals or plant Extracts | Citrullus lanatus | |
| Geographical availability | Egypt, Ethiopia, Libya, Sudan | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bcl-xL, Bax, Caspase 3, keratin 19, Vimentin, N-cadherin, Zeb1, Zeb2, BMI-1, CD44 | |
| Gene or Protein evidence | Our study in metastatic MDA-MB-231 cells showed that both ethanol and acetone pulp extracts decreased transcript levels of the anti-apoptotic genes BCL2 and BCLXL, and a reverse effect was observed for the pro-apoptotic genes BAX and caspase 3. Moreover, MDA-MB-231 cells treated with both these extracts demonstrated up-regulation of the epithelial gene keratin 19 and down-regulation of the mesenchymal genes, vimentin, N-cadherin, Zeb1 and Zeb2 compared to control, suggesting a suppressive impact of these extracts in epithelial to mesenchymal transition (EMT). In addition, these extracts inhibited colony and sphere formation with simultaneous reduction in the transcript level of the stemness associated genes, BMI-1 and CD44. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Overall, the results of this report suggest, for the first time, that colocynth fruit pulp extracts may block the proliferative as well as metastatic activity of breast cancer cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:291938-1 | |
| Safety | NA |