| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-119 | |
| Phytochemical name or plant extracts | Codonolactone | |
| PMID | 26549400 | |
| Literature evidence | The inhibitory effect of CLT was due to its ability to inhibit TGF-β signaling and Runx2 phosphorylation. | |
| IUPAC name | (4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4,4a,6,7,8,9-hexahydrobenzo[f][1]benzofuran-2-one | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Atractylodes lancea | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Runx2 | |
| Gene or Protein evidence | Data from western blotting showed that, in breast cancer cells, TGF-β1 stimulated the activation of Runx2, and CLT blocked the activation of Runx2. | |
| Target pathways | TGF-β signaling | |
| IC50 | NA | |
| Potency | Collectively, our present study demonstrated that CLT inhibited programming of EMT in vitro and in vivo, resulting in inhibition of motility of metastatic breast cancer cells. The inhibitory effect of CLT was due to its ability to inhibit TGF-β signaling and Runx2 phosphorylation. | |
| Cell line/ mice model | MDA-MB-468, MDA-MB-231, Five-to 6-week-old female NOD/SCID mice | |
| Additional information | NA | |
| PubChem ID | 155948 | |
| Additional PMIDs | 25190326 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:182976-1 | |
| Safety | NA |