| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-634 | |
| Phytochemical name or plant extracts | Clove | |
| PMID | 25276075 | |
| Literature evidence | This study aims to evaluate the cytotoxic activity of cloves toward MCF-7 human breast cancer cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract, Ethanolic extract, Essential oil | |
| Source of phytochemicals or plant Extracts | Syzygium aromaticum | |
| Geographical availability | Maluku | |
| Plant parts | Flower buds | |
| Other cancers | Breast cancer, Cervical cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Akt, p38 MAPK, JNK and Erk 1/2 pathways | |
| IC50 | Essential oil for 48h: 36.43 μg/mL against MCF-7 17.6 μg/mL against MCF-7 | |
| Potency | Cloves are natural products with excellent cytotoxicity toward MCF-7 cells, thus, they are promising sources for the development of anticancer agents. In both BSLT and MTT assays, the essential oil showed the highest cytotoxic effect, followed by ethanol and water extract. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HeLa, DU-145 | |
| Additional information | When both extracts were incubated at a higher concentration or for a longer period of 48 hours, the IC50 values of the ethanol extract and essential oil became much lower compared with those at 24 hours of incubation. This suggests that the ethanol extract and essential oil of cloves inhibit the MCF-7 human breast cancer cell lines in a time- and dose-dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | 25075040 25276075 33568035 28358602 22292639 30210543 32099733 33867344 28110253 23144548 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:601421-1 | |
| Safety | The LD50 concentration of essential oil in the 24 hours BSLT was 37 μg/mL. |