| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1922 | |
| Phytochemical name or plant extracts | Clematis hederagenin saponin (CHS) | |
| PMID | 29434869 | |
| Literature evidence | The results suggest that the hederagenin saponin extracted from Clematis ganpiniana offers great potential as a novel anti-breast cancer drug. | |
| IUPAC name | (9S)-9-hydroxy-2,2,6b,9,12a-pentamethyl-10-[(3,4,5-trihydroxyoxan-2-yl)oxy]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid saponin | |
| Source of phytochemicals or plant Extracts | Clematis ganpiniana | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Tibet | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | In addition, it upregulated the activities of caspase-3 and -9. In conclusion, CHS induced apoptosis in breast cancer cells through regulation of the mitochondrial apoptosis pathway. | |
| IC50 | NA | |
| Potency | The results suggest that the hederagenin saponin extracted from Clematis ganpiniana offers great potential as a novel anti-breast cancer drug. | |
| Cell line/ mice model | MCF-7 and MDA-MB-231 | |
| Additional information | The compound also induced apoptosis in breast cancer cells in a time-dependent manner. Further investigation into the underlying mechanisms of apoptosis induction in breast cancer cells showed that the compound significantly reduced mitochondrial Apaf-1 and cytochrome c proteins in breast cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:709716-1 | |
| Safety | NA |