| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1905 | |
| Phytochemical name or plant extracts | Cladosporol A | |
| PMID | 28728544 | |
| Literature evidence | Furthermore, immunofluorescence studies were carried to see the involvement of intrinsic pathway leading to mitochondrial dysfunction, cytochrome c release, Bax/Bcl-2 regulation and flowcytometrically measured membrane potential loss of mitochondria in human breast (MCF-7) cancer cells after Cladosporol A treatment. | |
| IUPAC name | (1aR,7R,7aR)-6,7-dihydroxy-3-(5-hydroxy-4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)-1aH,2H,7H,7aH-naphtho[2,3-b]oxiren-2-one | |
| Phytochemicals’ class or type of plant extracts | Epipolythiodioxopiperazine | |
| Source of phytochemicals or plant Extracts | Cladosporium cladosporioides | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21 | |
| Gene or Protein evidence | Cladosporol A also inhibited the assembiling of microtubules and induction of p21 a proapoptotic protein. Furthermore, Cladosporol A treatment also induced mild autophagic flux in human breast (MCF7) cell line. | |
| Target pathways | Cladosporol A induced apoptosis through ROS mediated mitochondrial pathway and increased p21 protein expression in MCF-7 cells in vitro. | |
| IC50 | 8.7 μM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Cladosporol A in human breast (MCF-7) cancer cell line. Cladosporol A treatment induces membrane potential loss of mitochondria, cytochrome c release, Bax upregulation and Bcl-2 down regulation, thereby inducing mitochondrial activation mediated apoptosis. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |