| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1847 | |
| Phytochemical name or plant extracts | Cladosporium oxysporum extract | |
| PMID | 25169499 | |
| Literature evidence | CONCLUSIONS: We propose that the fungal taxol contributes to growth inhibition in the human breast cancer cell through apoptosis induction via a mitochondrial mediated pathway, with possible potential as an anticancer therapeutic agent. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Cladosporium oxysporum | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NF-κB, Bcl-2, Bcl-xL, Bax, cyt-C, Caspase 3 | |
| Gene or Protein evidence | It was suggested that the extract may exert its anti-proliferative effect on human breast cancer cell line by suppressing growth, arresting through the cell cycle, increase in DNA fragmentation as well as down-regulation of the expression of NF-?B, Bcl-2 and Bcl-XL and up-regulation of pro-apoptotic proteins like Bax, cyt-C and caspase-3. | |
| Target pathways | The fungal taxol contributes to growth inhibition in the human breast cancer cell through apoptosis induction via a mitochondrial mediated pathway | |
| IC50 | 2.5 μM/ml against T47D | |
| Potency | We propose that the fungal taxol contributes to growth inhibition in the human breast cancer cell through apoptosis induction via a mitochondrial mediated pathway, with possible potential as an anticancer therapeutic agent. | |
| Cell line/ mice model | T47D | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |