| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-219 | |
| Phytochemical name or plant extracts | Citrus sphaerocarpa extract | |
| PMID | 26778161 | |
| Literature evidence | Polysaccharides from Korean Citrus hallabong peels inhibit angiogenesis and breast cancer cell migration. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polysachharide [four different polysaccharide fractions (HBE-I, -II, -III, and -IV)] | |
| Source of phytochemicals or plant Extracts | Citrus sphaerocarpa | |
| Geographical availability | Korea | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP9 | |
| Gene or Protein evidence | HBE-II also inhibited breast cancer cell migration, through downregulation of matrix metalloproteinase-9 (MMP-9) in MDA-MB-231 triple-negative breast cancer cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Therefore, inhibition of tube formation and MMP-9-mediated migration observed in HUVEC and MDA-MB-231 cells, respectively, are likely to be important therapeutic targets in triple-negative breast cancer metastasis. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The HBE polysaccharides significantly blocked tube formation of human umbilical vein vascular endothelial cells (HUVECs), at a concentration of 12.5 or 25 μg/mL. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:3017574-4 | |
| Safety | NA |