| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1082 | |
| Phytochemical name or plant extracts | Citrus lemon extract | |
| PMID | 33749513 | |
| Literature evidence | An antiproliferative bioassay involving neutral red-dye uptake was used to determine the anticancerous potential of plant extracts. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Citrus limon | |
| Geographical availability | Subtropical biome | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | JAK1, JAK2, TYK2, IRF7, IRF3 | |
| Gene or Protein evidence | lemon water extract was most effective with 32 dilutions with IC50 48.67%, by upregulating JAK1, JAK2, TYK2, IRF7 and IRF3 gene expressions of the JAK/STAT pathway. | |
| Target pathways | JAK/STAT pathway | |
| IC50 | NA | |
| Potency | C. limon inhibited the growth of both Vero and MDA-MB 231 cells. It suggested that C. limon has anti-cancer potential by inducing the JAK/STAT pathway. | |
| Cell line/ mice model | MDA-MB-231, Vero | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60454758-2 | |
| Safety | NA |