| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1849 | |
| Phytochemical name or plant extracts | Citrus aurantifolia extract | |
| PMID | 25276192 | |
| Literature evidence | New approach of breast cancer therapy is developed toward combination therapy with agents that have a specific molecular target. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Citrus aurantifolia | |
| Geographical availability | Introduced to : Angola, Assam, Bangladesh, Belize, Benin, Bolivia, Cambodia, Caroline Is., Cayman Is., Central American Pac, Chad, Christmas I., Cook Is., Costa Rica, Cuba, Dominican Republic, East Himalaya, El Salvador, Ethiopia, Fiji, Florida, Galápagos, Gambia, Gilbert Is., Guinea-Bissau, Gulf of Guinea Is., Haiti, India, Laos, Line Is., Malaya, Marianas, Marshall Is., New Caledonia, Niger, Niue, Oman, Pakistan, Puerto Rico, Sri Lanka, Trinidad-Tobago, Tuamotu, Venezuela, Vietnam, Windward Is. | |
| Plant parts | Peels | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bcl-2 | |
| Gene or Protein evidence | Evidence of apoptosis and protein expression of p53 and Bcl-2 indicated that both single applications and combinations of CPE and doxorubicin are able to increase apoptotic bodies of MCF-7 cells by increasing the proteins expression. | |
| Target pathways | PI3K/Akt pathway | |
| IC50 | 59 μg/mL against MCF-7 | |
| Potency | This result suggested that CPE could perform as co-chemotherapeutic agent with doxorubicin on breast cancer cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The result showed that CPE 6 μg/mL induced apoptosis and cell accumulation at G1 phase, while CPE 15 μg/mL induced apoptosis and cell accumulation at G2/M phase. The combination of doxorubicin 200 nM with CPE 6 μg/mL increased apoptosis induction than their single treatment, and cell accumulation at G2/M phase. | |
| PubChem ID | NA | |
| Additional PMIDs | 12222671 25276192 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:59599-2 | |
| Safety | NA |